7th French International Symposium
on CAR T Cells (CAR T Day)

September 6th, 7th and 8th, 2023

Organized by the Faculty of Medicine and Lille University Hospital.

Under the auspices of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC), The Société Française de lute contre les Cancers et les leucémies de l’Enfant et de l’adolescent (SFCE), The société Française d’Immunologie (SFI), The club d’ImmunoThérapie Cellulaire (CITC)The Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), The Intergroup Francophone du Myélome (IFM), and The Lymphoma Study Association (LYSA).

You can download the latest version of the program here

Wednesday September 6th, 2023

08:00 – Welcome and registration

09:45 – Introduction

Frédéric Boiron, General Director of Lille University Hospital TBC
Ibrahim Yakoub-Agha and Suman Mitra

Engineering the next-generation of CAR T-cells

Chairs: Ignacio Moraga (Dundee; Scotland) & chair(s) (city, country)

10:00 – Fighting fire with fire: Boosting T cell-based immunotherapies by mitochondrial transfer

Luca Gattinoni (Regensburg, Germany)

10:25 – Neoantigen Reactive TILs: Key to Next-gen Cell Therapies

Sri Krishna (Bethesda, USA)

10:50 – Exploring Cell-Specific Viral Entry Approaches to improve gene and cellular immunotherapy

Els Verhoeyen (Nice, FRANCE)

11:15 – Methods to edit T cells for cancer immunotherapy

Laurie Menger (Paris, France) TBC

11:40 – Biomarkers to inform CAR-T therapies

Joseph Melenhorst (Cleveland, USA)

12:00 – Coffee break

12:30 – 13:15

Keynote lecture

Chair(s): name(s) of chair(s) (city, country)

Marcela Maus (USA)

13:15 – Lunch break

Industrial Symposium I

Chair(s): name(s) of chair(s) (city, country)

14:00 – Title

Name of presenter (city, country)

14:30 – Title

Name of presenter (city, country)

Industrial Symposium II

Chair(s): name(s) of chair(s) (city, coutry)

15:00 – Title

Name of presenter (city, country)

15:30 – Title

Name of presenter (city, country)

16:00 – Coffee break


Special lecture : Pioneering the In Vivo Cell Engineering Approaches for cancer treatments

Chairs : Suman Mitra (Lille, France) & Ibrahim Yakoub-Agha (Lille, France)

Gill SAAR (Philadelphia, USA)

Session LYSA

Chair(s) :Franck Morschhauser (Lille, France) & Noël Milpied (Bordeaux, France)

17:00 – Blood transfusion in CAR T-cell therapy for lymphomas

Samuel vic (Rennes, France)

17:20 – ALYCANTE: CtDNA and PET scan

Marie-Hélène Delfau (Créteil, France)

17:40 – Title

Name of presenter (city, coutry)

18:00 –  Closing remarks

Thursday September 7th, 2023

08:30 – Welcome and registration

Session IFM

Chairs : Thierry Facon (Lille, France) & Philippe Moreau (Nantes, France)

09:00 – CAR T cells in MM from clinical studies to real life: Where are we ?

Xavier Leleu (Poitiers, France)

09:20 – Relapse after anti BCMA CAR T cells: Outcome and mechanisms of resistance

Bertrand Arnulf (Paris, France)

09:40 – Future directions for cellular immunotherapy in MM

Salomon Manier (Lille, France)

10:00 – Coffee break

10:20 – Group photo

Industrial Symposium III

Chair(s) : name(s) of chair(s) (city, country)

10:30 – Title

Name of presenter (city, country)

11:00 – Title

Name of presenter (city, country)

11:30 – 12:15

Keynote lecture: New insights into fine-tuning the actions of gc family cytokines

Chairs : Erwan Mortier (Nantes, France) & Suman Mitra (Lille, France)

Warren J. Leonard (Bethesda, USA)

12:15 – Lunch

Session SFGM-TC: CAR T-cell toxicity and patient’s management

Chairs : Stéphanie Nguyen (Paris), Raynier Devillier (Marseille)

13:10 – Stem cell transplantation as a backbone for modern cell- and gene therapy

Stephan Mielke (Stockholm, Sweden)

13:30 – Immune effector hematotoxicity : European Guidelines

Marion Subklewe (München, Germany)

13:50 – Place of Anakinra in ICANS

Jordan Gauthier (Seattle, USA) TBC

14:10 – Myeloid neoplasms following CAR T for lymphoid malignancies

Ibrahim Yakoub-Agha (Lille, France)

14:30 – Coffee break

Session CAR T beyond Leukemia and Lymphoma

Chairs: Geoffrey Guittard (Marseille, France) & Arnaud Scherpereel (Lille, France)

15:00 – B-cell Engineering

Michel Cogné (Rennes, France)

15:20 – CAR monocytes for cancer immunotherapy

Jean-Luc Perfettini (city, France)

15:40 – Personalized T-cell therapies for solid cancers

Alena Gros (city, Spain)

16:00 – Coffee break

Modulating the Tumor Microenvironment

Chairs : Christelle Harly (Nantes, France) & Emmanuel Donnadieu (Paris, France)

16:00 – Stemness and Maintenance of Treg lineage.

Rahul Roychoudhuri (Cambridge, UK) TB

16:50 – Lymphoma Microenvironment

Karin Tarte (Rennes, France)

17:10 – Metabolic barriers to cancer immunotherapy

Greg Delgoffe (Pittsburg, USA)

17:40 – ion channels in T-cell immunotherapy

Robert Eil (Oregon, USA)

18:00 – Closing remarks

20:00 – Gala dinner

Friday September 8th, 2023

08:30 – Welcome and registration

Session GRAALL & SFCE :

Chairs: Nicolas Boissel (Paris, France) & André Baruchel (Paris, France)

9:00 – New CAR T-cell development in T-ALL

Paul Maciocia (London, UK) TBC

9:20 – B-ALL: Are two targets better than one?

Ching-Hon Pui (Memphis, USA) TBC

9:40 – Title

Name of presenter (city, country)

Round table : point-of-care production

Chairs : Ibrahim Yakoub-Agha (Lille, France), Christian Chabannon (Marseille, France)

10:00 – Centralized production versus point-of-care production

Chrystel Marton (Lille, France)

10:10 – Difficulties and challenge for point-of-care production

Arnon Nagler (Tel Aviv, Israel)

0:20 – Academic vector production

Ulrike koehl (Liebzig, Germany)

10:30 – Round table

Olivier Boyer (Rouen, France), Jérôme Larghero (Paris, France), Camille Giverne (Rouen, France), Christophe Ferrand (Besançon, France), Arnon Nagler (Tel Aviv, Israel), Chrystel Marton (Lille, France).

11:00 – Coffee break

Symposium NOVARTIS

Chair(s): name(s) of chair(s) (city, country)

11:30 – Title

Name of presenter (city, country)

Academic session

Chairs: Louis Terriou (Lille, France) & Dominique Farge-Bancel (Paris, France)

12:00 – Incorporating radiation with Car T-cell therapy

Omran Saifi (Florida, USA)

12:20 – Boosting antitumoral T cell responses with the epichaperome inhibitor PU-H71 : perspectives for CAR T cell and other cellular immunotherapies

Monica Guzman (NY, USA)

12:40 – Infections and CAR T

David Beauvais (Lille, France)

13:00 – CAR-T cell therapy for Lupus

Georg Schett (city, Germany)

13:30 -Lunch break

SFI & CITC session : Harnessing immune signaling for innovative cell therapy

Chairs : Laurence Bataille (Paris, France) & Jacques Nunès (Marseille, France)

14:30 – Integrated approaches to dissect signaling in T cells

Romain Roncagalli (Marseille, France)

14:50 – Can we learn about CAR T cells by studying immune synapse formation ?

Claire Hivroz (Paris, France)

15:10 – Deciphering metabolic regulation in lymphocytes to improve future cell therapies

Antoine Marçais (Lyon, France)

15:30 – End of the meeting and conclusions

Suman Mitra & Ibrahim Yakoub-Agha