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Wednesday September 6th, 2023
08:00 – Welcome and registration
09:45 – Introduction
Frédéric Boiron, General Director of Lille University Hospital TBC
Ibrahim Yakoub-Agha and Suman Mitra
Engineering the next-generation of CAR T-cells
Chairs: Ignacio Moraga (Dundee, Scotland) & chair(s) (city, country)
10:00 – Fighting fire with fire: Boosting T cell-based immunotherapies by mitochondrial transfer
Luca Gattinoni (Regensburg, Germany)
10:25 – What studying neoantigen-specific TIL can teach as about human antitumor immunity
Sri Krishna (Bethesda, USA)
10:50 – Advancing Cancer Treatment through System and Synthetic Immunology: Exploring Novel Approaches in CAR T-Cell Engineering
Rocio Castellanos-Rueda (Zurich, Switzerland)
11:15 – Systematic identification of targets for advanced T-cell therapy using genome-scale CRISPR screens
Laurie Menger (Paris, France)
11:40 – Biomarkers to inform CAR-T therapies
Joseph Melenhorst (Cleveland, USA)
12:00 – Coffee break
12:30 – 13:15
Keynote lecture: Unraveling the Mechanisms Driving CAR T Cells and Their Therapeutic Implications
Chair(s): Alexis Cortot (Lille, France), Mattias Carlsten (Stockholm, Sweden)
Marcela Maus (USA)
13:15 – Lunch break
14:15-15:00
Special lecture : Pioneering the In Vivo Cell Engineering Approaches for cancer treatments
Chairs : Suman Mitra (Lille, France) & Ibrahim Yakoub-Agha (Lille, France)
Gill SAAR (Philadelphia, USA)
CAR-T cells therapies in Follicular Lymphoma (Symposium Novartis)
Chair: Roch Houot (Rennes, France)
15:00 – CAR-T in follicular lymphoma: present and future
Gabriel Brisou (Marseille, France)
15:30 -Enhancing the identification of patients and referral timing for CAR T cell-therapy in Relapsed/Refractory follicular lymphoma
Roch Houot (Rennes, France)
16:00 – Coffee break
Session LYSA
Chair(s) : Gandhi Damaj (Caen, France) & Noël Milpied (Bordeaux, France)
16:30 – ALYCANTE: Clinical results
Rock Houot (Rennes, France)
16:50 – ALYCANTE: CtDNA and PET scan
Marie-Hélène Delfau (Créteil, France)
17:10 – Blood transfusion in CAR T-cell therapy for lymphomas
Samuel vic (Rennes, France)
17:30 – Closing remarks
Thursday September 7th, 2023
08:30 – Welcome and registration
Session IFM
Chairs : Thierry Facon (Lille, France) & Philippe Moreau (Nantes, France)
09:00 – CAR T cells in MM from clinical studies to real life: Where are we ?
Xavier Leleu (Poitiers, France)
09:20 – Relapse after anti BCMA CAR T cells: Outcome and mechanisms of resistance
Bertrand Arnulf (Paris, France)
09:40 – co-receptors in the contexte of CD226 et CD137
Ludovic Martinet (Toulouse, France)
10:00 – Coffee break
10:20 – Group photo
CAR-T cells between past & future (BMS symposium)
Chair : Ibrahim Yakoub-Agha (Lille, France)
10:30 – First steps
Ibrahim Yakoub-Agha (Lille, France)
10:50 – What next?
Christian Chabannon (Marseille, France)
11:10 – Q&A round table
11:30 – 12:15
Keynote lecture: New insights into fine-tuning the actions of gc family cytokines
Chairs : Erwan Mortier (Nantes, France) & Suman Mitra (Lille, France)
Warren J. Leonard (Bethesda, USA)
12:15 – Lunch
Session SFGM-TC: CAR T-cell toxicity and patient’s management
Chairs : Stéphanie Nguyen (Paris), Ibrahim Yakoub-Agha (Lille, France)
13:00 – Infectious challenges and prophylactic strategies in CAR T cell therapy
Stephan Mielke (Stockholm, Sweden)
13:20 – Immune effector hematotoxicity : European Guidelines
Marion Subklewe (München, Germany)
13:40 – Place of Anakinra in CRS/ICANS
Nicolas Gazeau (Lille, France)
14:00 – Myeloid neoplasms following CAR T for lymphoid malignancies
Micha Srour (Lille, France)
14:20 – Coffee break
Session CAR T beyond Leukemia and Lymphoma
Chairs: Geoffrey Guittard (Marseille, France) & Arnaud Scherpereel (Lille, France)
14:40 – B-cell Engineering
Michel Cogné (Rennes, France)
15:00 – CAR monocytes for cancer immunotherapy
Jean-Luc Perfettini (city, France)
15:20 – Personalized T-cell therapies for solid cancers
Alena Gros (Barcelona, Spain)
15:40 – Universal CAR-MAIT cells, a promising approach in solid tumors
Sophie Caillat-Zucman (Paris, France)
16:00 – Addressing the Tumor Microenvironment to enhance the efficacy of CART cell therapy in solid tumors
Juan José Lasarte (Pamplona, Navarra, Spain)
16:20 – Coffee break
Modulating the Tumor Microenvironment
Chairs : Christelle Harly (Nantes, France) & Emmanuel Donnadieu (Paris, France)
16:50 – Stemness and Maintenance of Treg lineage.
Rahul Roychoudhuri (Cambridge, UK)
17:10 – Lymphoma Microenvironment
Karin Tarte (Rennes, France)
17:30 – Metabolic barriers to cancer immunotherapy
Greg Delgoffe (Pittsburg, USA)
17:50 – A novel approach to mitigate on-target off-tumor toxicity of CAR-T cells in the treatment of solid cancer
Robert Eil (Oregon, USA)
18:10 – Closing remarks
20:00 – Gala dinner
Friday September 8th, 2023
08:30 – Welcome and registration
Session GRAALL & SFCE :
Chairs: Nicolas Boissel (Paris, France) & André Baruchel (Paris, France)
9:00 – New CAR T-cell development in T-ALL
Paul Maciocia (London, UK)
9:20 – GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
Concetta Quintarelli (Roma, Italie) TBC
9:40 – Is there a best bridging before CAR T-cell therapy in b-ALL ?
André Baruchel (Paris, France)
Round table : point-of-care production
Chairs : Ibrahim Yakoub-Agha (Lille, France), Olivier Boyer (Rouen, France)
10:00 – Centralized production versus point-of-care production
Chrystel Marton (Lille, France)
10:10 – Difficulties and challenge for point-of-care production
Arnon Nagler (Tel Aviv, Israel)
10:20 – The CARAMBA project : an exemple of European collaboration
Halvard Bönig (Frankfurt, Germany)
10:30 – Academic vector production
Ulrike koehl (Liebzig, Germany)
10:40 – Round table
Halvard Bönig (Frankfurt, Germany), Olivier Boyer (Rouen, France), Jérôme Larghero (Paris, France), Camille Giverne (Rouen, France), Christophe Ferrand (Besançon, France), Ulrike koehl (Liebzig, Germany), Arnon Nagler (Tel Aviv, Israel), Chrystel Marton (Lille, France).
11:00 – Coffee break
New insights in the field of CAR T-cell therapy
Chairs: Louis Terriou (Lille, France) & Dominique Farge-Bancel (Paris, France)
11:30 – Incorporating radiation with Car T-cell therapy
Omran Saifi (Florida, USA)
11:50 – Boosting antitumoral T cell responses with the epichaperome inhibitor PU-H71 : perspectives for CAR T cell and other cellular immunotherapies
Monica Guzman (NY, USA)
12:10 – Infections and CAR T
David Beauvais (Lille, France)
12:30 – CAR-T cell therapy for Lupus
Georg Schett (city, Germany)
13:00 -Lunch break
SFI & CITC session : Harnessing immune signaling for innovative cell therapy
Chairs : Laurence Bataille (Paris, France) & Jacques Nunès (Marseille, France)
14:00 – Integrated approaches to dissect signaling in T cells
Romain Roncagalli (Marseille, France)
14:20 – Can we learn about CAR T cells by studying immune synapse formation ?
Claire Hivroz (Paris, France)
14:40 – Deciphering metabolic regulation in lymphocytes to improve future cell therapies
Antoine Marçais (Lyon, France)
15:00 – End of the meeting and conclusions
Suman Mitra & Ibrahim Yakoub-Agha