6th French International Symposium
on CAR T Cells (CAR T Day)

September 7th, 8th and 9th, 2022

Program 2022

Organized by the Faculty of Medicine and Lille University Hospital.
Under the auspices of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC), The Société Française de lutte contre les Cancers et les leucémies de l’Enfant et de l’adolescent (SFCE), The Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), The Intergroup Francophone du Myélome (IFM), and The Lymphoma Study Association (LYSA).

You can download the latest version of the program here

Wednesday September 7th, 2022

10:30 – Welcome and registration

11:30 – Lunch

12:15 – Introduction – Download here

Marc Hazzan, Dean of the faculty of Medicine,
Ibrahim Yakoub-Agha and Suman Mitra

12:30 – Keynote lecture : Past, present and future of immune cellular therapy

James N. Kochenderfer (NIH, Bethesda. USA)

Basics and translational immunotherapy

Chairs: Suman Mitra (Lille, France), Olivier Boyer (Rouen, France)

13:00 – Determinants of long-term persistence of functional CAR-T cells

Joseph Melenhorst (Cleveland, USA)

13:20 – Approaches to mitigate CAR T-cell exhaustion – Download here

Evan Weber (Philadelphia, USA)

13:40 – Enhancing adoptive T or NK cell homing to tumor sites

Mattias Carlsten (Karolinska Institute, Sweden)

14:00 – Understanding and exploiting public neoantigens targeted immune cell therapy in cancer

Christopher A. Klebanoff (MSKCC, New York, USA)

Symposium MILTENYI Biomedecine

Chair: Franck Morschhauser (Lille, France)

14:30 – Treatment options for elderly patients with r/r DLBCL

Peter Borchmann (Köln, Germany)

15:00 – Coffee break


Chair: Roch Houot (Rennes, France)

15:30 – Welcome and introduction

Roch Houot (Rennes, France)

15:35 – Integrating CAR-T cells in aggressive lymphoma today : Key learnings

Gabriel Brisou (Marseille, France)

15:50 – What are the imminent perspectives for CAR-T cells for LBCL ? – Download here
Vincent Camus (Rouen, France)

16:05 – How can we optimize CAR-T cells for aggressive lymphoma ?
Roch Houot (Rennes, France)

16:20 – Q&A and discussion
All faculty, moderated by Roch Houot

16:30 – Coffee break

Session LYSA

Chairs: Franck Morschhauser (Lille, France), Gandhi Damaj (Caen, France)

17:00 – Hematological and immune reconstitution : related toxicities

Marion Subklewe (München, Germany)

17:30 – Axi-cel versus tisa-cel in DLBCL – Download here

Emmanuel Bachy (Lyon, France)

17:50 – CAR-T cells therapy in T cell lymphoma – Download here

Paul Maciocia (London, UK)

18:10 – Management of DLBCL patients relapsing after CAR T-cell therapy

Roberta Di Blasi (Paris, France)

18:30 –  Closing remarks

Thursday September 8th, 2022

08:30 – Welcome and registration

Session: Other indications and novel immune cellar therapy technologies

Chairs: Chrystel Marton (Lille, France), Dominique Farge (Paris, France)

09:00 – CAR-Treg-cell therapy in auto-immune diseases

Georg Schett (Erlangen, Germany)

09:25 – TH17 CAR T-cells based therapy in solid tumor

Chrystal Paulos (Atlanta, USA)

09:50 – CAR-T cell therapy for MPN/MDS – Download here

Halvard Bönig (Frankfurt, Germany)

10:15 – CAR T-cells and solid organ transplantation

Julien Zuber (Paris, France)

10:40 – Synthetic immune cells able to eliminate senescent cells – Download here

Corina Amor (New york, USA)

11:00 – Coffee break

11:20 – Group photo

Session : emerging centers

Chairs : Halvard Bönig (Frankfurt, Germany), Micha Srour (Lille, France)

11:30 – Setting up a CAR-T Program : A Framework for Delivery – Download here

Ahmed, Syed Osman Ali (Riyadh, Saudi Arabia)

12:00 – Lunch

Session SFGM-TC: CAR T-cell toxicity and patient’s management

Chairs: Stéphanie Nguyen (Paris, France), Jacques-Olivier Bay (Clermont-Ferrand, France)

13:30 – French and European recommendations on patient’s management – Download here

Ibrahim Yakoub-Agha (Lille, France)

13:50 – Allo-HCT and CAR-T cells in NH lymphoma – Download here

David Beauvais (Lille, France)

14:10 – Neurological toxicity

Antoine Carpentier (Paris, France)

14:30 – Immunomonitoring – Download here

Marie-Thérèse Rubio (Nancy, France)

14:50 – EBMT/SFGM-TC registry

Christian Chabannon (Marseille, France)

15:10 – Coffee break

Session IFM

Chairs: Thierry Facon (Lille, France), Salomon Manier (Lille, France)

15:40 – Place of CAR-T cells in myeloma treatment

Xavier Leleu (Poitiers, France)

16:00 – Real life data of ice-cel – the French compassionate program

Bertrand Arnulf (Paris, France)

16:20 – Academic CAR-T cells in myeloma

Jean-Christophe Bories (Paris, France)

16:40 – Targeting ICAM-1 in Multiple Myeloma

Monica Guzman (NY, USA)

17:00 – Closing remarks

Friday September 9th, 2022

08:30 – Welcome and registration

Session GRAALL & SFCE:

Chairs: Nicolas Boissel (Paris, France), André Baruchel (Paris, France)

09:00 – Current data in children and AYA with ALL – Download here

M. Shannon Maude (Philadelphia, USA)

09:20 – Future developments (e.g. CAR Bispe, T-ALL …) – Download here

Persis Amrolia (London, UK)

09:50 – Is there still a need for assessing the place of CAR-T cells vs allo-HCT in ALL with Randomized Trials? – Download here

Jordan Gauthier (Seattle, USA)

10:30 – Coffee break

Symposium Novartis

Chairs: Nicolas Boissel (Paris, France), Roch Houot (Rennes, France)

11:00 – Impact of innovative therapies in children and young adults ALL patients – Download here

Nicolas Boissel (Paris, France)

11:15 – Re-thinking treatments for patients with refractory / relapsed FL
Roch Houot (Rennes, France)

Closing session

Chairs: Ibrahim Yakoub-Agha (Lille, France), Christophe Ferrand (Lille, France)

11:30 – Academic CAR-T cells for NHL

Arnon Nagler (Tel Aviv, Israel)

11:45 – Academic CAR-T cells for Meyloma

Carmen Sanges (Würsberg, Germany)

12:00 – CRISPR-dissection and -engineering of human T cells for future therapeutic applications

Kathrin Schumann (Munich, Germany)

12:15 – Visualizing CAR-T activity in tissue environment – Download here

Emmanuel Donnadieu (Paris, France)

12:30 – Conclusion and end of the CARTday 2022 meeting